Hemoglobin Zürich. II. Physicochemical Properties of the Abnormal Hemoglobin
نویسندگان
چکیده
منابع مشابه
The Abnormal Hemoglobin Syndromes
By IRwIN 1\i. WEINSTEIN, CARROLL L. SPURLING, HERMAN I’tLEIN AND THOMAS F. XECHELES I x PREVIOUS PUBLICATIONS,’ ,2 1e have reported that tagging human erythrocytes with radioactive chromium in the form of Na2Cr”O4 affords a simple, rapid and reproducible method for studying the survival of erythrocytes in normal subjects and patients with various hernatologic disturbances. By this method the on...
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The present paper reports a spectroscopic and kinetic study of the reaction with oxygen and carbon monoxide of (a) the abnormal hemoglobin Zürich (beta 63, E7 His leads to Arg), (b) its isolated abnormal chains (beta ZH), and (c) a reconstituted hybrid containing cobalt instead of iron on the normal alpha chains (Co alpha)2-(Fe beta ZH)2. The abnormal beta ZH chains, isolated from hemoglobin Zü...
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By T. H. J. HUISMAN, A. M. Dozy, B. E. HORTON AND J. B. WILsON T HE EXISTENCE of variants of normal human fetal hemoglobin ( HbFor a2y2 ) has been suggested in different reports in the literature. Variants of fetal hemoglobin with abnormal a-polypeptide chains have been described5 ”5 and some are well characterized.’0 Only one abnormality, namely the electrophoretically fast moving hemoglobin v...
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Hemoglobin variants in which a frameshift results in chain elongation are unusual. Hemoglobin Pakse (Hb Pakse) is an unstable hemoglobin with abnormal elongation, first described in Indochina. An alpha2-globin gene termination codon mutation, TAA -->TAT or Term -->Tyr, has been described in the pathogenesis of Hb Pakse. This abnormality causes a frameshift that elongates the alpha chain amino a...
متن کاملOn the Antigenic Properties of Hemoglobin
Sera produced by immunization with crystalline oxyhemoglobin react species-specifically with hemoglobin solutions. Evidence is presented that in this reaction the hemoglobin itself is the active substance. Conversion of oxyhemoglobin into methemoglobin, carbon-monoxy hemoglobin, or cyanhemoglobin does not alter the response to the precipitating immune serum. Not only the hemoglobin of homologou...
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ژورنال
عنوان ژورنال: Blood
سال: 1962
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v20.3.272.272